Catherine and Sara deal with the death of what at first seems to be a transvestite. Later during autopsy they find out that the make-up he seemed to be wearing was actually facepaint, he was a clown. Grissom, Nick, and Warrick deal with the death of a man in a homeless area. They found out he worked in a recovery center for drug users.
Monica and Chandler visit their potential new house and bring Joey along, who's still upset about them moving, so he's determined to change their minds. Meanwhile, Phoebe learns that she can legally change her name to whatever she wants, so she considers something more exotic. Also, Ross gets tenure at his job, while Rachel's unfortunate job interview actually leads her to some new career opportunities.
When the overwhelmingly strong and gregarious Calvin, Vanessa's dad, begs Michael to give him a job at Kyle Trucking, Michael does so reluctantly and his worst fears are realized. Calvin's way of dealing with customers and merchandise leaves a little to be desired, and now Michael must find a way to get rid of the man without getting himself hurt in the process. Meanwhile, Claire gets Franklin to help her with her science paper.
While his father is awaiting surgery, Clark befriends a young boy, Garrett whose brother Vince just died from liver failure. However, everyone is shocked when Vince shows up alive and seemingly well - until his liver starts failing again. In a desperate attempt to keep his brother alive, Garrett straps a Kryptonite bomb to himself and demands that Vince be given Jonathan's liver or he will blow up the building.
Dave examines what the daily life of rapper Lil John might be like and tries to imagine how the internet would look if it was an actual place. Also featuring musical guest Anthony Hamilton.
Archer goes to extreme lengths to save an abandoned nest of Xindi-Insectoid eggs ready to hatch.
McCoy faces an uphill battle in proving that witnesses to the murder of a drug mule were bribed, intimidated, and eventually murdered on the orders of the drug dealer accused of the crime.
Ryan and Marissa begin their life together as "friends", but both discover that it might be harder to do than to say. Theresa drops into Newport for work, and another visit. Julie and Luke realize the meaning of "booty calls", and Seth and Summer make a declaration.
He's back, Former VP John Hoynes, who resigned in sex scandal, makes a bid for political resurrection by trashing Barlet and Leo in a tell-all book. But it's C.J. who's taking the news the hardest.
Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.
Hank wants to attract more people to Dog River by building a World's Biggest something and roping Brent into it while Oscar thinks Lacey has a crush on him.
An FBI agent talks to Lem in an attempt to catch up with Baron. Ahmad is a suspect for a purse snatching and is under police custody. Also, After Teri sleeps with a client her sisters find out.
After being breathed on by an ancient sarcophagus, Fred contracts a mystery illness and lies near death while Angel and his friends try to figure out what's wrong with her.
Before a romantic evening with Eric, Donna realizes that she's missed taking one of her birth control pills. Both of them completely freak out and seek out Kitty's advice. Fez is still extremely angry about losing Suzy to Kelso, so he "dumps" Kelso and returns everything his former friend ever gave him. Everyone in the gang tries to console the unhappy couple while Suzy plots to reunite them.
When Arthur tries to sell Spence his adjoining burial plot, he winds up selling it to Spence's mother, Veronica. Doug is assigned a new delivery route and is freaked out by a man at one of his daily stops who always answers the door wearing nothing but a towel around his waist.
Roz is disappointed when she is unable to get Alice tickets to a concert by children's performer Nanny G. After his family reveals that he used to be married to her, Frasier agrees to help Roz secure tickets.